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*Crystallisation

*Crystallisation

A fully automated crystallisation pipeline to achive high-throughput with short crystallisation plate processing times, high reproducibility, and increased efficiency of the screening process.

*Electron Microscopy

*Electron Microscopy

The high-resolution electron microscope has evolved into a sophisticated instrument that is capable of routinely providing quantitative structural information on the atomic scale.

*Imaging

*Imaging

Imaging techniques including fluorescence microscopy provide an efficient and unique approach to study fixed and living cells because of their versatility, specificity, and high sensitivity.

*Macromolecular Interactions

*Macromolecular Interactions

Instruct offer a wide range of techniques to study macromolecular interactions, including circular dichroism, surface plasmon resonance (SPR), thermal shift assay and calorimetry.

*Magnetic Resonance Techniques

*Magnetic Resonance Techniques

NMR allows three-dimensional structural and dynamic information to be obtained in conditions as close as possible to physiological ones. Functional processes can be followed in living cells, and transient protein-protein interactions can be investigated.

*Mass Spectrometry

*Mass Spectrometry

Mass spectrometry is the dominant technology in the field of proteomics, enabling the indentification and quantification of cellular proteins and their modified forms.

*Nanobody Discovery

*Nanobody Discovery

Nanobodies are single chain antibodies which have revolutionary applications in structural biology. Our Nanobody Discovery service is accessible to all Instruct researchers.

*Protein Production

*Protein Production

Instruct offers a wide range of expression systems for recombinant proteins including Bacterial, Baculovirus, Cell-free, Mammalian and Yeast. Our techniques allow for expression of challenging proteins along with expert protein purification systems.

*Sample Characterisation

*Sample Characterisation

Sample characterisation techniques include Analytical Ultracentrifugation (AUC) and Multi Angle / Dynamic Light Scattering (MALS).

*X-Ray Approaches

*X-Ray Approaches

Instruct-ERIC offer a wide range of X ray approaches to determine the three dimensional shape of proteins at the atomic level.

Proteomic Mass Spectrometry

Proteomic Mass Spectrometry

Identifying and quantifying cellular proteins

Solid State NMR

Solid State NMR

Structure and dynamics of bio-solids