Crystallisation allows the 3D structure of macromolecules to be revealed through X-ray diffraction. Some molecules form crystals easily, others require more sophisticated techniques to generate the repeating structures necessary for analysis. Instruct offer a fully automated crystallisation pipeline to achieve high-throughput with short crystallisation plate processing times, high reproducibility, and increased efficiency of the screening process.
NMR allows three-dimensional structural and dynamic information to be obtained in conditions as close as possible to physiological ones. Functional processes can be followed in living cells, and transient protein-protein interactions can be investigated.
Instruct's services include protein expression, cloning and high throughput expression, and protein purification. Our techniques allow for expression of challenging proteins along with expert protein purification systems.