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Crystallisation

Crystallisation:

Crystallisation allows the 3D structure of macromolecules to be revealed through X-ray diffraction. Some molecules form crystals easily, others require more sophisticated techniques to generate the repeating structures necessary for analysis. Instruct offer a fully automated crystallisation pipeline to achieve high-throughput with short crystallisation plate processing times, high reproducibility, and increased efficiency of the screening process.

Electron Microscopy

Electron Microscopy:

The high-resolution electron microscope has evolved into a sophisticated instrument that is capable of routinely providing quantitative structural information on the atomic scale.

Imaging

Imaging:

Imaging techniques including fluorescence microscopy provide an efficient and unique approach to study fixed and living cells because of their versatility, specificity, and high sensitivity.

Magnetic Resonance Techniques

Magnetic Resonance Techniques:

NMR allows three-dimensional structural and dynamic information to be obtained in conditions as close as possible to physiological ones. Functional processes can be followed in living cells, and transient protein-protein interactions can be investigated.

Mass Spectrometry

Mass Spectrometry:

Mass spectrometry is the dominant technology in the field of proteomics, enabling the identification and quantification of cellular proteins and their modified forms.

Molecular Biophysics

Molecular Biophysics:

Instruct offer a wide range of techniques to study macromolecular interactions, including circular dichroism, surface plasmon resonance (SPR), thermal shift assay and calorimetry.

Nanobody Discovery

Nanobody Discovery:

Nanobodies are single chain antibodies which have revolutionary applications in structural biology. Our Nanobody Discovery service is accessible to all Instruct researchers.

Protein Production

Protein Production:

Instruct's services include protein expression, cloning and high throughput expression, and protein purification. Our techniques allow for expression of challenging proteins along with expert protein purification systems.

Proteomic Mass Spectrometry

Proteomic Mass Spectrometry:

Identifying and quantifying cellular proteins

X-Ray Techniques

X-Ray Techniques:

Instruct-ERIC offer a wide range of X ray approaches to determine the three dimensional shape of proteins at the atomic level.