Joint INSTRUCT-CAPRI Workshop on Integrative Modelling of Protein-Protein Interactions

Date: 01-Apr-2019 13:00 CEST to 02-Apr-2019 18:00 CEST

Contact: Alexandre Bonvin


This workshop on integrative modelling of protein-protein interactions will run from the 1st - 2nd April 2019 at EMBL-EBI, Hinxton, starting at lunch time on the Monday. It will run prior to the 7th CAPRI Assessment Meeting, which will also take place at the Wellcome Genome Campus (3rd to 5th April 2019).  For information about the venue and the CAPRI meeting please refer to events website

The aim of this practical course is to train young researchers in the computational modelling of protein-protein interactions using a variety of data sources, including X-ray crystallography, NMR, SAXS, cross-linking mass spectrometry and Cryo-EM. The course will introduce and make extensive use of common software and e-science portals to facilitate the adoption of the methods and techniques by the students in their everyday work.  Each session (2 hours) will consist of an introductory lecture followed by a hands on computer practical.

Lead contact: Prof. Dr. Alexandre M.J.J. Bonvin –

Number of participants: 25 students



Registration is free for participants from INSTRUCT countries and £250 from other countries. Visit the website to find out if you are from a participating INSTRUCT country

Please note accommodation is not included in the registration fee.

Registernow!  Registrations close 8 March 2019.


  • Introduction to protein-protein docking: sampling and scoring          

Practical: Flexible docking with SwarmDock             

Paul A. Bates, and Raphael A.G. Chaleil, Francis Crick Institute, London, UK       


  • Introduction to data-driven docking    

Practical: Integrative docking with HADDOCK        

Alexandre M.J.J. Bonvin and Panos Koukos, Bijvoet Center for Biomolecular Research, Utrecht, NL       


  • Protein structure prediction     

Practical: Modelling protein structures and variants: Phyre, PhyreRisk, Missense3D and EzMol    

Michael J.E. Sternberg, Lawrence Kelley and Charles Tochukwu, Imperial College London, London, UK             


  • The validation and verification of protein structure    

Practical: Hands-on assessment of structural quality  

Gerard Kleywegt, EMBL European Bioinformatics Institute, Cambridge, UK         


  • Integrative structure determination of macromolecular assemblies    

Practical: Determination of macromolecular structure using Cryo-EM data  

Sony Malhotra and Maya Topf, Institute of Structural and Molecular Biology, London, UK           


  • Protein-protein binding affinities        

Practical: Modelling interaction strength using machine learning      

Iain H. Moal, EMBL European Bioinformatics Institute, Cambridge, UK  

EMBL-EBI Hinxton, United Kingdom

Joint INSTRUCT-CAPRI Workshop on Integrative Modelling of Protein-Protein Interactions