CCP4 is a software suite for Macromolecular X-Ray Crystallography, for every stage of the crystallographic structure solution process, from processing X-ray diffraction images through to producing images and movies for presentations and publications.

CCP4 Online provides the following programs and pipelines:

Balbes

An automated Molecular Replacement (MR) pipeline – Balbes integrates into one system all the components necessary for solving a crystal structure by Molecular Replacement

MrBUMP

An automated Molecular Replacement (MR) pipeline – Given a target sequence and experimental structure factors, it will search for homologous structures, create a set of suitable search models from the template structures, do molecular replacement, and test the solutions with some rounds of restrained refinement.

Zanuda

Space group and crystallographic origin validation

jsPISA

Calculation and analysis of macromolecular surfaces and interfaces

AMPLE

Automated ab initio search model generation for molecular replacement.

SHELX

Automated SHELXC/D/E structure solution pipeline for fast routine experimental phasing. Accepts data in XDS, Scalepack, SHELX hkl or mtz formats and outputs phases and a poly-Ala trace. If a protein sequence is provided, BUCCANEER and REFMAC complete the structure.

CRANK2

Automated structure solution pipeline for experimental phasing using maximum likelihood methods.

MoRDa

MoRDa is a pipeline for molecular replacement protein structure solution based on its own domain database. Models relevant to the target sequence are further adjusted before molecular replacement search.

SIMBAD

Sequence-independent molecular replacement, good for identifying if your crystal contains a contaminant protein.

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