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Strasbourg provides an integrated environment for structural studies of protein and complexes from sample preparation to structure determination.

Instruct Centre - France 1

Instruct Flagship Service/Technology

Cryo Electron Microscopy on Titan Krios at IGBMC-CERBM Strasbourg

The center offers access for three-dimensional structure determination using cryo-electron microscopy (cryo-EM). The centre has expertise in all aspects of single particle analysis from the automated acquisition of large data sets to image analysis . Access to the following instrumentation is provided: The Titan Krios cryo electron microscope equiped with a CMOS (FEI FALCON 4K*4K) high-sensitivity direct electron detector camera. The Tecnai F30 Polara cryo electron microscope allows high-resolution SPA and CET automated data collection. The Tecnai F20 is equipped with a FEG operated at 100keV or 200keV.

Instruct service/technology information

Instruct Centre - France 1

The Strasbourg center provides a cutting-edge technological environment for integrative structural biology approaches, from the molecular to the cellular level, with an emphasis on protein production linked with preparation of samples for EM and crystallography.


Protein engineering and production are essential tools for structural, biophysical and functional studies as well as for biotechnology and medical applications. The Strasbourg center offers a state-of-the-art infrastructure for the production of biomolecules and biomolecular complexes in E. coli, yeast, insect cells (baculovirus expression system) as well as in mammalian cells using an attenuated vaccinia virus vector. The Strasbourg platform has a unique expertise on production of recombinant multi-protein complexes as well as on purification of endogenous complexes using the TAP-tag technology in yeast.


Strasbourg provides core-technologies for structure determination by crystallography, cryo-EM and tomography. Strasbourg is a center of expertise for crystrallographic analysis of protein-protein and protein-nucleic acid complexes (nano and micro-automated screening and HTP crystal production, data collection and structure determination) and cryo-electron microscopy/tomography (Hight resolution cryo-EM, cryo electron tomography using up to date equipment (Polara and Titan microscopes and Falcon detectors)

The center also offers access to

- biophysical plateform to monitor protein properties and function, including protein stability, protein complex formation, oligomerisation and protein interactions,

- shape determination by SAXS.

- NMR (700MHz, 600MHz with cryo-probe, protein and nucleic acid isotope labelling, solution structure determination & dynamics, translational diffusion measurement)

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